44. J. Ricardo M.Pinto, M. Gabriela T. C. Ribeiro, Adélio A. S. C. Machado, O desafio na escolha dos solventes em síntese – o workup como exemplo, Quim. Nova, 42, 8, 971-982, 2019.
2019-09-26

Autores:
J. Ricardo M.Pinto
M. Gabriela T. C. Ribeiro
Adélio A. S. C. Machado *

Instituições:
LAQV/REQUIMTE, Departamento de Química da Faculdade de Ciências da Universidade do Porto
*Departamento de Química e Bioquímica da Faculdade de Ciências da Universidade do Porto

Resumo:
A procedure for the assessment and optimization of the greenness of solvents in synthesis was developed. It involves two optimization components, aiming at the optimization of both the intrinsic greenness of the solvents and their efficiency to improve the overall green performance of the synthesis, evaluated with mass, energy and time greenness metrics. The procedure was tested in a study with educational purpose for assessing and improving the greenness of solvents used in the workup step of a ionic liquid synthesis that involves a solventless reaction step (1-hexyl-3-methylimidazolium chloride) and proved useful to systematize the aspects that should be considered to choose the solvents used in the workup. The results show that there may be a competition in the solvent choice between a safer solvent and a more hazardous solvent with better performance of the overall synthesis process, which requires optimization for reaching a balanced solution. The study illustrates the problems of the substitution of solvents in synthetic processes to improve greenness, as well as the importance of the utilization of a battery of greenness metrics for evaluation of the overall synthesis outcomes.

http://educa.fc.up.pt/investigacao_artigo.php?id=191



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